A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Nanotechnology offers a range of options to lead to biology. Listed here I'll current illustrations wherever nanofabrication – the ability to make confined structures with dimensions at will – is used to examine the biophysics of one molecules and cells. I'll existing some illustrations from our lab:
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‘It absolutely was basically a make a difference of choosing up a guide on mobile biology and starting to study. I'd come from a globe of extremely-substantial vacuums, cryostats and quantum phenomena, and now I used to be working at home temperature with molecular biology kits.
Non-equilibrium folding of specific DNA molecules recaptured up to 1000 periods in a very sound condition nanopore
This yielded a breakthrough. In just just a few months, we were being capable to evaluate transport through someone one-walled carbon nanotube. Determined by low-temperature experiments by an excellent PhD student in my group, Sander Tans (now a valued colleague and professor at Delft College of Engineering having an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up real quantum wires with incredibly extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
You are a Christian. If you can make this type of artificial mobile, would you be one particular step closer to God, or would the purpose of God have diminished rather all over again?
Circulation-pushed rotary motors which include windmills and water wheels generate purposeful procedures in human society. Though examples of these kinds of rotary motors also aspect prominently in mobile biology, their artificial design at the nanoscale has remained difficult. Listed here we exhibit circulation-pushed rotary motion of a self-arranged DNA nanostructure that is definitely docked on to a nanopore in a skinny stable-point out membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking on to the reliable-point out nanopore, and subsequently shows a sustained unidirectional rotary movement of up to twenty rev s−one.
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Bulk-floor coupling identifies the mechanistic link involving Min-protein styles in vivo As well as in vitro
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Nanoscientist Cees Dekker can be an amiable and flamboyant person who seems Significantly younger than the sixty two several years he essentially is – trendy glasses, psychedelic shirt, partaking smile – although not a single to squander time. He usually takes his time, but not more than essential.
2008, initially observation of protein-coated DNA translocation as a result of nanopores; fixed the origin of the electrophoretic drive on DNA in nanopores; found out an important velocity maximize of microtubules in electric powered fields; learned an cees dekker anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of noise in carbon nanotubes in liquid
Illustration (2) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is proven in gray, the rim from the pore is highlighted in purple, and a 3D rendering in the movement of the DNA rod is shown.